INTRODUCTION/OBJECTIVES: Endophthalmitis is defined as inflammation of the internal ocular structures and it could be of exogenous or endogenous origin. Endogenous bacterial endophthalmitis (EBE) accounts for about 2%-6% of all cases and occurs during bacteremia when infective agent penetrates the blood- ocular barriers.. Endogenous panophthalmitis (EP) results in the most extensive ocular involvement withinflammation of periocular tissues . All therapeutic options are aimed to stop the spreading of infective inflammation from orbital space into cavernous sinus and is considered to be a life saving treatment

Juri Mandić, Jelena

Kovačević, Petra

Lovrić, Matej

Lukšić, Martina

Samardžić, Nika

English

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CR47DIAGNOSIS AND MANAGEMENT OF TUMOR LYSIS SYNDROME IN A 10-YEAR-OLD PATIENTMarin Bobana, Matej Jelićba School of Medicine, University of Zagrebb University Hospital Centre Zagreb, Department of Pe-diatrics, Division of Hematology and Oncology, ZagrebDOI: https://doi.org/10.26800/LV-144-supl2-CR47 Marin Boban 0000-0002-5552-0295, Matej Jelić 0000-0001-6685-180XKeywords: Burkitt’s, lymphoma, Non-Hodgkin, Tumor lysis syndromeINTRODUCTION/OBJECTIVES: Burkitt's lymphoma is a highly aggressive B-cell non-Hodgkin lymphoma character-ized by the translocation of the MYC gene on chromosome 8. Tumor lysis syndrome (TLS) is an oncologic emergency con-dition resulting from rapid tumor cell death and release into the bloodstream.CASE PRESENTATION: A 10-year-old boy was admitted due to suspicion of an ongoing malignantprocess. Laboratory data showed a hyperleukocytosis (WBC 39.7 x109/L), thrombocytopenia (platelets 27x109/L), anemia (hemoglobin 88 g/L), elevated lactate dehydrogenase (LDH 10510 U/L). A bone marrow aspiration was performed and di-agnosis of Burkitt’s lymphoma was established. After initiat-ing treatment according to protocol NHL-BFM-2012 with pre-phase to reduce tumor mass, patient laboratory data showed elevated potassium (4.7 mmol/L), elevated uric acid (24.4 mmol/L), and LDH kept rising to a level of 15100 U/L. Also, early signs of damaged kidney function were noticed which included oliguria and elevated creatinine levels (277 umol/L). Patient was transfered into ICU where he immediately started taking rasburicase along with pre-phase. Treatment with ras-buricase lasted for 8 days. During the patient’s stay at ICU, other signs of TLS occurred, including hyperphosphatemia and hypocalcemia, but with no seizures or cardiac symptoms so we decided not to treat hypocalcemia.CONCLUSION: Since it is an oncologic emergency, especial-ly in patients with diagnosis of NHL, it is crucial to anticipate the risk and recognize early signs of tumor lysis syndrome and proceed with decision making according to the grade of TLS. It is challenging to treat electrolyte imbalance in patient with TLS owing to the risk of crystallizing calcium phosphate.CR48Endogenous Endophthalmitis with Panophthalmitis – case reportPetra Kovačevića, Matej Lovrića, Nika Samardžića, Mar-tina Lukšićb, Jelena Juri Mandića,ca School of Medicine University of Mostar b Medical School University of Zagrebc Department of Ophthalmology, University Hospital Centre ZagrebDOI: https://doi.org/10.26800/LV-144-supl2-CR48 Petra Kovačević 0000-0001-5449-3427, Matej Lovrić 0000-0001-9882-2632, Nika Samardžić 0000-0002-1423-8453, Martina Lukšić 0000-0002-8933-3930, Jele-na Juri Mandić 0000-0003-0211-7491Keywords: endophthalmitis, panophthalmitis, hematog-enous disseminationINTRODUCTION/OBJECTIVES: Endophthalmitis is defined as inflammation of the internal ocular structures and it could be of exogenous or endogenous origin. Endogenous bacterial endophthalmitis (EBE) accounts for about 2%-6% of all cases and occurs during bacteremia when infective agent penetrates the blood- ocular barriers.. Endogenous panophthalmitis (EP) results in the most extensive ocular involvement withinflam-mation of periocular tissues . All therapeutic options are aimed to stop the spreading of infective inflammation from orbital space into cavernous sinus and is considered to be a life saving treatment.CASE PRESENTATION: We report a case of endogenous en-dophthalmitis and panophthalmitis. A 80- year-old female pa-tient presented with amaurosis and pain in the left eye. She was previously hospitalized and treated for diabetes mellitus and epigastric pain,and hemathemesis.Ocular sSymptoms occurs subsequently seven days later. After complete diagnostic work up and conservative treatmenturgent enucleation was required.CONCLUSION: EP and EBE is a rare, life-threatening disease which require rapid an accurate treatment. Diabetes mellitus could predispose its development. The conditions should be suspected in older patients with comorbidities and without trauma or surgery in medical history. A multidisciplinary ap-proach is needed.17th Croatian Student Summit Liječ Vjesn 2022; godište 144; (Supl. 2)68CASE REPORTS

Endogenous Endophthalmitis with Panophthalmitis – case report

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