Komparativna terapeutska svojstva ekstrakta češnjaka i metformina na hiperglikemiju, hiperkolesterolemiju i hipertrigliceridimiju kod štakora s dijabetesom tipa 1 induciranim aloksanom

Abstract

The current pilot study was conducted to compare the triple effect of garlic extract and metformin on hyperglycaemia, hypercholesterolaemia, and hypertriglyceridaemia in alloxan-induced type 1-like diabetic rats. Wistar rats were randomly divided into four groups. Control group included normal rats. The second group included alloxan-induced type 1-like diabetic rats, receiving no treatment. The other two groups of diabetic rats were orally treated with 0.75 g of garlic extract per kg of body weight and 0.05 of metformin g per kg of body weight respectively for four weeks. The pharmacological impact of garlic compounds on serum glucose and lipids as opposed to the glucose-lowering and lipid-lowering was highlighted in these experiments. These results revealed that garlic extract has a triple action on hyperglycaemia, hypertriglyceridemia, and hypercholesterolemia. Its effect on hyperglycaemia is long lasting, and more pronounced compared to the metformin. Interestingly, it had a regulatory effect on glycaemia as highlighted in the control group. This work is licensed under a Creative Commons Attribution 4.0 International License.Ovo pilot-istraživanje provedeno je da bi se usporedio trostruki učinak ekstrakta češnjaka i metformina na hiperglikemiju, hiperkolesterolemiju i hipertrigliceridemiju kod štakora s dijabetesom tipa 1 induciranim aloksanom. Štakori Wistar nasumično su bili podijeljeni u četiri skupine. Kontrolna skupina sadržavala je normalne štakore. Druga skupina bili su netretirani štakori s dijabetesom (dijabetes tipa 1, induciran aloksanom). Preostale dvije skupine štakora s dijabetesom liječene su četiri tjedna ekstraktom češnjaka doziranim 75 g po kilogramu tjelesne težine, odnosno metforminom u dozi 0,05 g po kilogramu tjelesne težine. Navedeni spojevi unosili su se oralnim putem. U istraživanjima naglašen je farmakološki utjecaj spojeva iz češnjaka na glukozu i lipide u serumu. Dobiveni rezultati pokazali su da ekstrakt češnjaka ima trostruko djelovanje na: hiperglikemiju, hipertrigliceridemiju i hiperkolesterolemiju. Njegov učinak na hiperglikemiju dugotrajan je i izraženiji u usporedbi s metforminom. Zanimljivo je da je djelovao regulacijski na glikemiju. Ovo djelo je dano na korištenje pod licencom Creative Commons Imenovanje 4.0 međunarodna