Dabbagh, Ali

English

Journals Portal, Shahid Beheshti University of Medical Sciences

 Vol 7, No 1, Winter 2022 1 Editorial  Regenerative Medicine: Fact or Myth?    Tis a goblet that earns the Mind's praise;  One hundred kisses upon its forehead man pays. This potter of Fate makes his delicate pot so,  And alas! from his hand to the ground it strays. Omar Khayyam, 1048 -1131  Regenerative medicine is a novel interdisciplinary discipline in medicine dealing with the production of new or re-engineered tissues (either functional or living) to use the product instead of a tissue or an organ (1); the source of this new tissue or organ could be human or animal cells, tissues or organs, and the goal are to restore the function of the tissue or the organ (2). Is there any role for regenerative medicine in anesthesiology and perioperative medicine? There seem to be challenging when answering this question. First of all, the perioperative management of the organs could be considered as one of the main goals. Perioperative protective effects of regenerative medicine are nowadays more than just a hypothesis. In this issue of the Journal of Cellular and Molecular Anesthesia, Tabashi, et al, have reviewed the role of regenerative medicine in perioperative organ protection through Hypoxia-Inducible Factors (HIF), over several major organs including brain, heart, kidney, lung, and liver; they have demonstrated “a pioneering role of regenerative medicine to prevent perioperative complications” (3). In other words, regenerative medicine could be potentially one of the most important tools in the hands of anesthesiologists for clinical perioperative organ protection during the next couple of years. However, the studies regarding the role of regenerative medicine in anesthesiology are more than the field of the operating room and include areas like critical care (4), chronic pain therapy (5), and even, the management of the COVID-19 patients (6). This broad-spectrum application of regenerative medicine leads us to the point that we could use this novel discipline as a “routine clinical tool” in our daily clinical management of anesthesiology and perioperative medicine so soon; a technique long-learned by living cells from the beginning of life and keeping its pace forever; as Khayyam quoted “earns the Mind's praise”!   References 1. Mason C, Dunnill P. A brief definition of regenerative medicine. Regen Med. 2008;3(1):1-5. 2. Jacques E, Suuronen EJ. The Progression of Regenerative Medicine and its Impact on Therapy Translation. Clin Transl Sci. 2020;13(3):440-50. 3. Tabashi S, Tajbakhsh A, Dahi M, Dabir S, Vosoughian M, Moshari M. Regenerative Medicine and Perioperative Hypoxic Organ Damage: Targeting Hypoxia-Inducible Factors. J Cell Mol Anesth. 2022;7(1):58-65. 4. Keane C, Jerkic M, Laffey JG. Stem Cell-based Therapies for Sepsis. Anesthesiology. 2017;127(6):1017-34. 5. Han YH, Kim KH, Abdi S, Kim TK. Stem cell therapy in pain medicine. Korean J Pain. 2019;32(4):245-55. 6. Basiri A, Pazhouhnia Z, Beheshtizadeh N, Hoseinpour M, Saghazadeh A, Rezaei N. Regenerative Medicine in COVID-19 Treatment: Real Opportunities and Range of Promises. Stem Cell Rev Rep. 2021;17(1):163-75.  Ali Dabbagh, MD  Professor of Cardiac Anesthesia Anesthesiology Research Center, Shahid Beheshti University of Medical Sciences,  Tehran, Iran; Email: alidabbagh@yahoo.com  Please cite this article as: Dabbagh, A. Regenerative Medicine: Fact or Myth? J Cell Mol Anesth. 2022;7(1):1. https://doi.org/10.22037/jcma.v7i1.37891. 

Regenerative Medicine: Fact or Myth?

https://journals.sbmu.ac.ir/jcma/article/download/37891/28497

Regenerative Medicine: Fact or Myth?

Abstract

Similar works

Full text

Available Versions

Journals Portal, Shahid Beheshti University of Medical Sciences