Kouwenhoven, W.M.

The mid- and hindbrain harbor two essential monoaminergic neuronal populations: the mesodiencephalic dopaminergic (mdDA) neurons in the midbrain and the serotonergic (5HT) neurons in the hindbrain. Both systems innervate multiple regions in the forebrain and are involved in the guidance of our mood, motility and motivation guided behavior. The population of mdDA neurons can be divided in the substantia nigra (SNc) and the ventral tegmental area (VTA). An important difference between these dopaminergic nuclei is revealed during the evolution of Parkinson's Disease (PD). The mdDA neurons of the SNc are progressively lost, whereas the mdDA neurons of the VTA are (mostly) spared. The subsequent loss of dopaminergic signaling in the striatum results in tremors, rigidity and depression in patients suffering from PD.We investigate the origin story of the mdDA neuron in order to understand the mdDA system in the healthy, adult brain as well as in the adult brain during pathological conditions. We examined the molecular pathway of transcription factors Engrailed 1, Pitx3 and Nkx2.9, that are required to code mdDA neurons. Furthermore, we aimed to unravel the molecular coding that define the molecular and functional differences between SN and VTA neurons. Together this work contributes to the general knowledge of the developing mdDA neurons and the sensitivity to programmed cells death that characterizes the SN subset of mdDA neurons

International Migration, Integration and Social Cohesion online publications

UvA-DARE is a service provided by the library of the University of Amsterdam (https://dare.uva.nl)UvA-DARE (Digital Academic Repository)The rise and fall of mesodiencephalic dopaminergic neuronsMolecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodiencephalic neuronsKouwenhoven, W.M.Publication date2016Document VersionOther versionLicenseOtherLink to publicationCitation for published version (APA):Kouwenhoven, W. M. (2016). The rise and fall of mesodiencephalic dopaminergic neurons:Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodiencephalic neurons.General rightsIt is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s)and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an opencontent license (like Creative Commons).Disclaimer/Complaints regulationsIf you believe that digital publication of certain material infringes any of your rights or (privacy) interests, pleaselet the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the materialinaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letterto: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. Youwill be contacted as soon as possible.Download date:26 Jul 2022NSWEMolecular programming by transcription factorsEngrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodiencephalic neuronsTHE RISE AND FALLOF MESODIENCEPHALICDOPAMINERGIC NEURONSWillemieke M. KouwenhovenTHE RISE AND FALL OF MESODIENCEPHALIC DOPAMINERGIC NEURONSWMK2016UITNODIGINGVoor de openbare verdediging van het proefschriftTHE RISE AND FALL OF MESODIENCEPHALIC DOPAMINERGIC NEURONSMolecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neuronsWoensdag 21 december 2016 11.00 uurAula der Universiteit Singel 4111012 XM AmsterdamNa afloop van de promotie bent u van harte uitgenodigd voor de receptie ter plaatseWillemieke Kouwenhovenwillemieke.kouwenhoven@gmail.com7584 Rue BerriMontréal, Québec, H2R 2G7CanadaParanimfenEva van Meeteren-Naninck e.f.g.naninck@uva.nlRicardo Paapricardopaap@gmail.comNSWEMolecular p ogramming by transcription factorsEngrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodi ncephalic neuronsTHE RISE AND FA LOF MESODIENCEPHALICDOPAMINERGIC NEURONSWillemieke M. KouwenhovenTHE RISE AND FALL OF MESODIENCEPHALIC DOPAMINERGIC NEURONSWMK2016UITNOD GINGVoor de openbar  v rdedi ing van het proefschriftTHE RISE AND FALL OF MESODIENCEPHALIC DOPAMINERGIC NEURONSMolecular p ogramming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodi ncephalic neuronsWoensdag 21 december 2016 11.00 uurAula der Universiteit Singel 4111012 XM AmsterdamNa afloop van de pr moti  bent u van harte uitgeno igd voor de recep ie ter plaatseWillemieke Kouwenhovenwill mieke.kouwenhoven@gmail.com7584 Ru  BerriMontréal, Québec, H R 2G7CanadaParanimfenE  van M eteren-Naninck e.f.g.naninck@uva.nlRicardo Paapricardo aap@gmail.comThe rise and fall ofmesodiencephalic dopaminergicneuronsMolecular programming by transcription factorsEngrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodiencephalic neuronsWILLEMIEKE M. KOUWENHOVENTHE RESEARCH PRESENTED IN THIS THESIS WAS PERFORMED IN THE MOLECULARNEUROSCIENCE LABORATORY AT THE SWAMMERDAM INSTITUTE FOR LIFESCIENCES, AMSTERDAM, THE NETHERLANDS.THE RESEARCH WAS FINANCIALLY SUPPORTED BY AN NWO VICI GRANT(865.09.002, THE NETHERLANDS) TO M.P.S.THE PRINTING OF THIS THESIS WAS SUPPORTED BY THE GENEROSITY OF* STICHTING ALKEMADE-KEULS,* DE PARKINSON VERENIGING,* OPA A.J. KOUWENHOVEN.ISBN: 978-94-6233-478-6COVER DESIGN: SKINNY LINNYLAY OUT: WILLEMIEKE M. KOUWENHOVENPRINTED BY: GILDEPRINT© WILLEMIEKE M. KOUWENHOVEN, THE NETHERLANDS, 2016The rise and fall ofmesodiencephalic dopaminergicneuronsMolecular programming by transcription factorsEngrailed 1, Pitx3, and Nkx2.9 during thedevelopment of mesodiencephalic neuronsACADEMISCH PROEFSCHRIFTter verkrijging van de graad van doctoraan de Universiteit van Amsterdamop gezag van de Rector Magnificusprof. dr. ir. K.I.J. Maexten overstaan van een door het College voor Promotiesingestelde commissie,in het openbaar te verdedigen in de Aula der Universiteitop woensdag 21 december 2016, te 11.00 uurdoorWILLEMIEKE MARIA KOUWENHOVENgeboren te GoudaPROMOTIE COMMISSIEPROMOTOR: Prof. dr. M.P. SmidtCOPROMOTOR: dr. L.P. van der HeideOVERIGE LEDEN:PROF. DR. E. ARONICA Universiteit van AmsterdamPROF. DR. J.P.H. BURBACH Universiteit UtrechtPROF. DR. E.M. HOL Universiteit van AmsterdamDR. A. KOROSI Universiteit van AmsterdamPROF. DR. P.J. LUCASSEN Universiteit van AmsterdamFACULTEIT: Faculteit der Natuurwetenschappen, Wiskunde enInformaticaWERKEN EN FEESTEN VORMT SCHOONE GEESTEN- PROF.DR. JOHANNA WESTERDIJK (1883 - 1961)CONTENTSCHAPTER 1 9MESODIENCEPHALIC DOPAMINERGIC NEURONS: THE ORIGIN STORYCHAPTER 2 31SPECIFICATION OF DOPAMINERGIC SUBSETS INVOLVES INTERPLAY OF EN1 AND PITX3CHAPTER 3 61ENGRAILED 1 SHAPES THE DOPAMINERGIC AND SEROTONERGIC LANDSCAPE THROUGHPROPER ISTHMIC ORGANIZER MAINTENANCE AND FUNCTIONCHAPTER 4 85PITX3 IS ESSENTIAL FOR SUBSTANTIA NIGRA DEVELOPMENT BY ORCHESTRATINGNEURONAL MIGRATION AND SURVIVAL: A POSSIBLE ROLE FOR FGF13CHAPTER 5 111PITX3 AND EN1 DETERMINE THE SIZE AND MOLECULAR PROGRAMMING OF THEMESODIENCEPHALIC DOPAMINERGIC NEURONAL POOLCHAPTER 6 135NKX2.9 PROGRAMS MESODIENCEPHALIC DOPAMINERGIC NEURONS EARLY IN DEVELOPMENTCHAPTER 7 163GENERAL DISCUSSIONCHAPTER 8 187ENGLISH SUMMARY//NEDERLANDSE SAMENVATTINGCHAPTER 9: ADDENDA 197LIST OF PUBLICATIONSCURRICULUM VITAEDANKWOORD: DE WE IN WETENSCHAP

English

The rise and fall of mesodiencephalic dopaminergic neurons:Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neurons

https://pure.uva.nl/ws/files/6817505/00_Front_matter.pdf

The rise and fall of mesodiencephalic dopaminergic neurons:Molecular programming by transcription factors Engrailed 1, Pitx3, and Nkx2.9 during the development of mesodiencephalic neurons

Abstract

Similar works

Full text

Available Versions

International Migration, Integration and Social Cohesion online publications