Probleme actuale ale morfologiei: Materialele Conferinţei ştiinţifice internaţionale
Abstract
Caredra histologie, citologie și embriologie, Labortorul Morfologie, Universitatea de Stat de Medicină și Farmacie „Nicolae Testemițanu”, Chişinău, Republica Moldova, Conferința Ştiinţifică Internaţională ”Probleme actuale ale morfologiei” dedicată celor 70 de ani de la fondarea Universității de Stat de Medicină și Farmacie „Nicolae Testemiţanu”, Chişinău, 15-16 octombrie 2015Abstract
Background: The first distinctive feature in the development of mammary glands is the apparition of milk lines that
is followed by the formation of 5 pairs of the placodes, which outgrowths to form mammary buds. Later, the buds give
rise tubular branched structures. These structures represent the primordial of lactiferous ducts, which from 18th day of
embryonic development stop to differentiate until the puberty. The major events that occur during the breast development
are strongly connected to cyclic hormonal modifications in pregnancy, lactation and menopause.
At the puberty occurs the branching of ductal excretory system – a process controlled by a broad spectrum of molecular factors. These are the hormones, growth factors, matrix active substances, metaloproteinases (MMP), and the
components of immune system. The aim was to highlight the molecular factors involved in the control of mammary gland
development at different embryonic and post-natal stages.
Conclusions: Molecular factors, involved in mammary development have diverse pathways and origin. Sophisticated
interactions of these factors determine step-like development and permanent rearrangement of the gland. Any disturbance
within these signaling pathways may lead to appearance of different pathologies: from morphological abnormalities to
malignancies. As a result, understanding of these mechanisms represents a theoretical basis necessary to elaborate a new
strategy of diagnosis and therapeutic management of breast carcinoma
