The purpose of the present study was to investigate the fracture resistance of computer aided endo-crowns versus conventional core-supported computer aided full crowns. Ninety human teeth were collected, 30 for each type (maxillary central incisors, maxillary 1st premolars and maxillary 1st molars). Specimens were divided into 3 groups (n=10) according to restoration used: 1) PC: Post-core and crown; 2) NC: Nayyar core and crown and 3) EC: Endo-crown. Each group was further subdivided into 3 subgroups according to the tooth used: I (Incisor), P (Premolar) and M (Molar). For group PC: Fiber post (Radix, Dentsply Maillefer) were cemented using resin cement (Calibra Dual Cure, Denstply Detrey GmbH). For group NC: 3 mm of gutta percha of every canal was removed. For groups PC and NC, after etching and bonding of root-face, transparent core former (Coltène/ Whaledent) was filled with SDR (Smart Dentine Replacement, Dentsply Detrey GmbH) and inverted onto root-face and cured. All specimens were individually scanned and thermocycled for 1000 cycles then submitted to compression test using universal testing machine (Instron 8874; Instron Corp.) Fracture was confirmed by sudden drop in load readings. Subgroup IPC scored the highest mean among group I and subgroup PNC scored the highest mean among group P. One-Way ANOVA detected significant differences among groups I and M with p\u3c 0.05 in I and M groups. Regarding P group, P-value was \u3e 0.05 indicating no significant differences among group. Endocrown showed the highest fracture resistance means in molars, while Nayyar core and crown showed the highest fracture resistance means in premolars. However, post-core and crown revealed the highest fracture resistance means in incisors
