Burimamide, a specific histamine H2-receptor antagonist, is an effective inhibitor of histamine and pentagastrinstimulated gastric acid secretion in the innervated pig stomach. Pepsin secretion, and acid secretion from denervated gastric pouches, were not significantly depressed by burimamide in the dose used in this study. Atropine inhibited pentagastrin- but not histaminestimulated gastric acid secretion from the innervated and denervated portions of the pig stomach.S. Afr. Med. J., 48, 1985 (1974)