Existing catch data for the whole of the Volta lake from 1969 to 2004 and those for certain segments of the lake (Strata II, III, and IV) covering various periods were analysed in relation to lake levels, to find out changes in catch trends and species composition. The study was undertaken as a baseline activity aimed at enhancing fisheries productivity and management of the lake. Higher catches were made at the inception of the lake, with about 65,000 t being recorded in 1969. This dropped and fluctuated between 36,000 anct48,000 t from 1971 to 1994. Catches kept increasing rapidly from 1995 with about 80,000 t being recorded in 1999, the highest in the history of the lake. In relation to annual fake water level fluctuations, high catches were made during periods of low water level compared to periods of high water level. On the long term, decreasing lake water level corresponded with higher fish catches. There was a change frominsectivorous fish species (e.g., Chrysichthys, Schilhe and Synodontis) at the initial stages of the formation of the lake to those with vegetarian food habits dominated by the tilapias. The dominance oftilapias in catches, which persisted till the early parts of the 1990s, has given way to Chrysichthys spp., suggesting that the composition of fish species in the lake is still undergoing changes 45 years after its formation