In this review, classification and phylogeny of genus Artemisia L. is discussed. Its centers of diversity lie in the temperate and cold temperate regions of the Eurasia, North America and Asia. Artemisia has two basic chromosome numbers, with ploidy levels x=9 and x=8. Chromosome number in diploid is most often 2n=18 or 16. The genus is divided into five large groups Absinthium DC., Artemisia L., Dracunculus Besser, Seriphidium Besser and Tridantatae (Rydb.) McArthur. Its phylogeny was based on the two hypothesized evolutionary trends, loss of fertility in the disc florets and loss of ray florets. Recently its molecular phylogeny based on internally transcribed spacer (ITS), externally transcribed spacer (ETS) regions of the DNA and chloroplast DNA suggested that the genus Artemisia is a monophyletic but it could not resolve the problem of infra-generic classification. This study revealed that there is need to search new genome regions to establish a natural classification based on modern molecular techniques