Bajelan, Arezoo

Barikani, Ameneh

Gheibi, Dr. Nematollah

Kalhor, Mehri

Pashazadeh, Fatemeh

Samiee-Rad, Fatemeh

Zarabadi‑Pour1, Simin

Qazvin University of Medical Sciences Repository

Original Article | Iran J Pathol. 2020; 15(1): 106-116 Vol.15 No.1 Winter 2020                                                                                   IRANIAN JOURNAL OF PATHOLOGY Iranian Journal of Pathology | ISSN: 2345-3656 Comparison of Diagnostic Methods in Detection of Squamous Cell Abnormalities in Iranian Women with Abnormal Pap’s Smear Test and Associated Demographic and Issues  Fatemeh Samiee Rad1 , Mahdi Ghaebi2 , Simin Zarabadipour3 , Arezoo Bajelan3,  Fatemeh Pashazade3, Mehri Kalhor4, Amane Barikani5  1. Department of Pathology, Metabolic Disease Research Center, Qazvin University of Medical Sciences, Qazvin, Iran  2. General Physician, Qazvin University of Medical Sciences, Qazvin, Iran  3. Qazvin University of Medical Sciences, Qazvin, Iran  4. Department of Reproductive Health, Tarbiat Modarres University, Tehran, Iran 5. Department of Epidemiology, Qazvin University of Medical Sciences, Qazvin, Iran KEYWORDS  ABSTRACT  Atypical Cervical Squamous Cells,  Cervical Cancer,  Colposcopy,  Cytology,  Pathology,  Pap smear  Scan to discover online    Background & Objective: Premalignant lesions of cervix have increased dramatically in recent years. Early diagnosis and management of abnormalities have an effective role in preventing the invasion of the disease and also in timely treatment. This study aimed to compare diagnostic methods in the detection of squamous cell abnormalities with abnormal Pap smear test. Methods: This cross-sectional study was performed on 1000 women with abnormal Pap smears in 2007-2018. Sampling was performed with simple method. All samples were subjected to an immediate assessment of colposcopy and histopathology if suspected. The checklist included demographic information as well as symptoms, cytopathology, colposcopy and histopathology findings. Data analysis was performed using descriptive and statistical analysis (P<0.05). Results: A significant relationship between histopathology and Pap smear findings was found (P=0.009), also there was a significant correlation between histopathology and colposcopy findings (P=0.001). However, there was no significant relationship between clinical symptoms and histopathology findings (p=0.8). Sensitivity , specificity , positive and  negative predictive value of Pap smear were 43%, 65.9%, 75.4%, 32.2% and of colposcopy were 74.7%, 39.5%, 75%, 39.1%, and of clinical symptoms were 72.6%, 28.1%, 71.1%, 29.7%, respectively. Conclusion: Pap smear findings have the appropriate diagnostic accuracy in comparison with colposcopy and histopathology findings for screening and diagnosis of squamous intra-epithelial lesions. Also, there was higher sensitivity of colposcopy compared with Pap smear to detect cervical lesions. Therefore, it is advisable to use these methods simultaneously. Main Subjects:  Gynecologic Pathology  Received 25 Sep 2019; Accepted 15 Feb 2020; Published Online 19 Feb 2020;            10.30699/ijp.2020.114626.2248       PMCID:               PMID:  Corresponding Information: Mehri Kalhor, PhD student of Reproductive health, Tarbiat Modarres University, Tehran, Iran   Email: mkalhor20@gmail.com Copyright © 2020. This is an open-access article distributed under the terms of the Creative Commons Attribution- 4.0 International License which permits Share, copy and redistribution of the material in any medium or format or adapt, remix, transform, and build upon the material for any purpose, even commercially.  Introduction One of the most common cancers among women around the world is cervical cancer (1). Nearly 80% of cervical cancer cases occur in developing countries (2). Cervical cancer is the second most common cause of cancer-related death among women worldwide, with over 500,000 new cases diagnosed annually and about 50% mortality rate in Asia (3).  Based on a report by the National cancer registry center of Iran, the mean age specific incidence rate of cervical cancer was 2.5 in 100,000 individuals (range: 0.4 (Zanjan, Iran) - 4.1 (Fars, Iran)) and this cancer was the 2nd  most common gynecological cancer among Iranian women (4,5).   Today, fortunately the prevalence of cervical cancer in Muslim countries, including Iran is less but the mortality rate is significant (6).  According to several studies, more than 80% of Iranian known cases of cervical cancer had been positive for Human papillomavirus (HPV) (7). HPV oncogene is a known risk factor for the development of cervical cancer (8), but there are other risk factors such as: smoking, promiscuous sexual behavior, sexually transmitted diseases, multi partnership, partner's sexual behavior, nutrition, socioeconomic level, genetic and patient’s hormonal and immunological status (9). Thus, cervical cancer can be prevented by using the HPV 

Comparison of Diagnostic Methods in Detection of Squamous Cell Abnormalities in Iranian Women with Abnormal Pap’s Smear Test and Associated Demographic and Issues

http://eprints.qums.ac.ir/11323/1/Comparison%20of%20Diagnostic%20Methods%20in%20Detection%20of%20Squamous%20Cell%20Abnormalities%20in%20Iranian%20Women%20with%20Abnormal%20Pap%E2%80%99s%20Smear%20Test%20and%20Associated%20Demographic%20and%20Issues.pdf

Comparison of Diagnostic Methods in Detection of Squamous Cell Abnormalities in Iranian Women with Abnormal Pap’s Smear Test and Associated Demographic and Issues

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