The inñuence of single (4 mg/mouse) and multiple (1 mg/mouse/day for 5 consecutive days) injections of PGM on some hepatic enzymes, lipid peroxide generation in serum and liver and hepatic lysosomal membrane permeability was investigated. The studies performed showed that a single injection of PGM in vivo changed temporarily the permeability of lysosomal membranes, lipid peroxidation products and, when administered in vitro, modulated superoxide anion production and did not affect the activity of lysosomal membrane enzymes. Multiple injections of PGM caused no significant changes in the examined parameters. Although the metabolic changes were time-limited and, from the toxicological point of view, provoked transient effects, the results obtained may be of importance when using PGM in combined chemo-immunotherapy
