Predicting Differences in Model Parameters with Individual Parameter Contribution Regression Using the R Package ipcr

Abstract

Unmodeled differences between individuals or groups can bias parameter estimates and may lead to false-positive or false-negative findings. Such instances of heterogeneity can often be detected and predicted with additional covariates. However, predicting differences with covariates can be challenging or even infeasible, depending on the modeling framework and type of parameter. Here, we demonstrate how the individual parameter contribution (IPC) regression framework, as implemented in the R package ipcr, can be leveraged to predict differences in any parameter across a wide range of parametric models. First and foremost, IPC regression is an exploratory analysis technique to determine if and how the parameters of a fitted model vary as a linear function of covariates. After introducing the theoretical foundation of IPC regression, we use an empirical data set to demonstrate how parameter differences in a structural equation model can be predicted with the ipcr package. Then, we analyze the performance of IPC regression in comparison to alternative methods for modeling parameter heterogeneity in a Monte Carlo simulation.Peer Reviewe