The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

A Urani; AW Zobel; BS McEwen; C Garcia-Lecumberri; C López-Rubalcava; DA Gutman; DH Overstreet; DH Overstreet; DM Nielsen; DNC Jones; DR Britton; DR Britton; Emily M. Jutkiewicz; F Borsini; F Holsboer; F Holsboer; F Holsboer; G Griebel; G Griebel; G Liebsch; GB Makara; Hani Houshyar; I Zebrowska-Lupina; James H. Woods; JH Broadbear; Kenner C. Rice; Ling-Wei Hsin; LV Scott; MD Bellis De; ME Keck; MG Spina; MJ Detke; PA Rittenhouse; PM Plotsky; R Alonso; RS Mansbach; S Chaki; S Watson; SC Heinrichs; SC Heinrichs; Susan K. Wood; T Deak; T Skrebuhhova; Y-Q Jiang

The effects of CRF antagonists, antalarmin, CP154,526, LWH234, and R121919, in the forced swim test and on swim-induced increases in adrenocorticotropin in rats

Authors: A Urani
AW Zobel
BS McEwen
C Garcia-Lecumberri
C López-Rubalcava
DA Gutman
DH Overstreet
DH Overstreet
DM Nielsen
DNC Jones
DR Britton
DR Britton
Emily M. Jutkiewicz
F Borsini
F Holsboer
F Holsboer
F Holsboer
G Griebel
G Griebel
G Liebsch
GB Makara
Hani Houshyar
I Zebrowska-Lupina
James H. Woods
JH Broadbear
Kenner C. Rice
Ling-Wei Hsin
LV Scott
MD Bellis De
ME Keck
MG Spina
MJ Detke
PA Rittenhouse
PM Plotsky
R Alonso
RS Mansbach
S Chaki
S Watson
SC Heinrichs
SC Heinrichs
Susan K. Wood
T Deak
T Skrebuhhova
Y-Q Jiang
Publication date: 1 July 2005
Publisher: 'Springer Science and Business Media LLC'
Doi

Abstract

Exposure to extreme stress has been suggested to produce long-term, detrimental alterations in the hypothalamic–pituitary–adrenal (HPA) axis leading to the development of mental disorders such as depression. Therefore, compounds that block the effects of stress hormones were investigated as potential therapeutics for depression.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46365/1/213_2005_Article_2164.pd