The study of localised oxygen saturation in blood vessels can shed light on the etiology and progression of
many diseases with which hypoxia is associated. For example, hypoxia in the tendon has been linked to early
stages of rheumatoid arthritis, an auto-immune inflammatory disease. Vascular oximetry of deep tissue presents
significant challenges as vessels are not optically accessible. In this paper, we present a novel multispectral
imaging technique for vascular oximetry, and recent developments made towards its adaptation for minimally
invasive imaging. We present proof-of-concept of the system and illumination scheme as well as the analysis
technique. We present results of a validation study performed in vivo on mice with acutely inflamed tendons.
Adaptation of the technique for minimally invasive microendoscopy is also presented, along with preliminary
results of minimally invasive ex vivo vascular oximetry
