先天性表皮水疱症は厚生省による特定疾患治療研究対象疾患で,いわゆる「難病」指定疾患である.表皮水疱症では,日常生活で外力が加わる部位に反復する水疱を臨床症状の主体とし,軽微な外力による水疱発生が基本であるが,病変活発な時期では特に誘因なく発生する場合もあるという.著者らは,7年間にわたって表皮水疱症接合部型の男児に理学療法を実施してきた.体表面が外界と接触するということは乳幼児の感覚一運動学習過程において必要不可欠な体験であるにもかかわらず,水疱発生によってそのことが阻害され結果的に運動発達の遅れを呈した.今回,問題を残しながらも普通小学校への就学ゴールに達したので,これまでの理学療法経過と若干の考察を加えて報告する.The purpose of this paper is to report on the course and physical therapy for epidermolysis bullosa. Epidermolysis bullosa is designated as a specific rare disease by the Ministry of Health and Welfare. The clinical feature is repeated blister formation that occurs following mechanical stimulation in daily living. The blisters may occur without cause especially at an active time of morbid change, although these are actually caused by slight stimulations. It is absolutely indispensable for sensori-motor learning in the baby that the body surface make contact with the environment. Motor learning is based on having experiences with the interaction between perception and motor. However, it is guessed that no comfort was experienced by the patient via sensory information from the skin. It is probable that he experienced of continuous pain and pruritus, felt as itching of the entire body. Therefore, it is inferred that biased perceptions would be generated and learned. In addition, blisters, erosions, and markedly fragile skin were actually aggravated by sensory inputs made to facilitate developmental intervention. Therapeutic exercise for the patient has been going on since four months from birth, but the patient has been continuing to exhibit retarded motor development. However, the patient was able to enter school normally in spite of having a few problems at present