Objective: To estimate serum Total Sialic Acid (TSA) levels in different grades of oral squamous cell carcinoma and to accessit`s utility as a tumor marker in this cancer.Materials and Methods: This study was conducted in 68 adult subjects equally divided into two groups, healthy individualsand patients with oral squamous cell cancer. Under aseptic precautions venous blood was drawn and serum was separated.Estimationof serum total sialic acid level was done according to Spectrophotometeric method of Plucinsky. Statistical analysis was carriedout by using SPSS 19.Results: Total subjects in the study included were 58.82% males and 41.17% females. Mean age of oral cancer patients was48.05 ± 8.82 years. There was significant male predominance with P<0.05. Oral cancer was most common in Tobacco+ Chaliya+ Areca nut and Gutka+pan groups. Mean serum total sialic acid (TSA) level in control group was 60.2 ± 4.27 mg/dl, whereasit was 99.1 ± 18.30 mg/dl in oral cancer group. It was significantly increased in oral cancer group when compared to controlgroup with P value < 0.01. There was progressive elevation in mean serum TSA level in oral squamous cell carcinoma,Conclusion:Estimation of serum total sialic acid level (TSA) in different grades of oral squamous cell carcinoma showedpositive relation with stage of malignancy, specifically with the tumor burden. It can be used as a diagnostic biomarker in oralsquamous cell cancers
