Doctors are currently observing an increase in the incidence of measles in Moscow and other cities in Russia and all over the world. Such an increase is primarily caused by parent's refusal to accept vaccination for their children. We have reviewed the main issues related to this acute infectious disease, analyzed the epidemiological situation in different countries (including Russia), and presented the main preventive measure, which is vaccination. In addition to that, some authors reported various types of exanthema, including measles-like, in patients with coronavirus infection, which is widespread now. The aim of this article is to draw the attention of practitioners to the typical initial and main clinical symptoms of measles, stages of rash, specific disease characteristics in patients of different ages, and complications. We have provided a rationale for a new treatment regimen for measles that includes a recombinant α-interferon (Viferon) and an immunomodulator with antiviral action (inosine pranobex; Groprinosin)