Background: In recent years, time-restricted feeding, alternate day fasting, and the Daniel Fast have garnered attention as potential dietary interventions to combat obesity. Objective: To compare the effects of various dietary models on measures of body composition and physical performance in male C57BL/6 mice. Methods: 60 young C57BL/6 male mice were assigned to a diet of time-resticted feeding, alternate day fasting, the Daniel Fast, caloric restriction, a high-fat diet, or a standard rodent chow for 8 weeks. Body composition and run time to exhaustion were determined. Results: Compared to the high-fat ad libitum grounp, all groups displayed significantly less weight and fat mass gain and non-significant changes in fat free mass. Additionally, although not statistically significant, all groups displayed greater run time to exhaustion, relative to the high-fat ad libitum group. Conclusion: The Daniel Fast, time-restricted feeding, and alternate day fasting may improve body composition and physical performance as compared to a hight-fat diet
