Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010)American Society for Reproductive Medicin

Güler, Zeynep Banu

Leventoğlu, Alev

Oktay, Kutluk

Sönmezer, Murat

Uzdoğan, Andaç

Çil, Aylin Pelin

Fertility and Sterility

English

Ufuk Universitesi Akademik Acikerisim Sistemi

Comparison of characteristics and IVF outcomes between two groups.S98 AbstractsPregnancy(n¼125)Non-pregnancy(n¼453) P valueAge(years) 33.5  0.3 35.3  0.2 < .001FSH (mIU/mL) 5.0  0.2 5.7  0.2 .020Unexplained(%) 25.6 (32/125) 28.7 (130/453) NSMale factor(%) 34.4 (43/125) 41.7 (189/453) NSFemale factor(%) 52.8 (66/125) 45.4 (205/452) NSPeak E2(mIU/mL) 2207.3  154.1 1873  66.1 .026jNRO-NLOj 2.9  0.2 2.9  0.1 NSjNRO-NLOj / NTOTAL 100 (%)30.3  2.2 41.8  1.6 < .001All the continuous variables are present in mean  SE.CONCLUSION: We observed prognostic value of the difference innumber of oocytes between two ovaries to total oocytes ratio which isindependent of patient’s age in IVF cycles. Further studies exploringthe presence of inter-ovarian control mechanism and its clinical implica-tion is needed.P-16 Tuesday, October 26, 2010OBESITY IS ASSOCIATED WITH LOWER SERUM AMH LEVELSIN WOMEN WITH DIMINISHED OVARIAN RESERVE (DOR).E. Buyuk, D. B. Seifer, E. Illions, R. Grazi, H. Lieman. Department of Ob-stetrics and Gynecology and Women’s Health, Albert Einstein College ofMedicine/Montefiore’s Institute for Reproductive Medicine and Health,Hartsdale, NY; Genesis Fertility & Reproductive Medicine, Brooklyn,NY.OBJECTIVE: To investigate the association between body mass index(BMI) and serum AMH levels in reproductive age women with dimin-ished ovarian reserve (DOR) diagnosed by elevated baseline FSH.DESIGN: Cross sectional observational study.MATERIALS AND METHODS: Two hundred and ninety women (ages:21-50) were evaluated for infertility between 2007- 2010 and were includedin this study. Baseline serum FSH levels were measured on day 2 or 3 of thecycle. Serum AMH levels were drawn randomly, unrelated to day of the cy-cle. Wilcoxon rank-sum test, multiple regression analysis and Spearman’srank correlation were used for statistical analysis. P<0.05 was consideredsignificant.RESULTS: BMI correlated negatively with serum AMH in women withelevated baseline FSH (>10IU/L) (r¼ -0.27, p¼0.001) but not in womenwith normal baseline FSH (10IU/L or less). Among women with elevatedbaseline FSH, AMH was 43% lower in women with high BMI (>25) com-pared to women with normal BMI (25 or less) (p¼0.0002). This associationpersisted after controlling for age (p¼0.03). In marked contrast, serum AMHlevels were no different between high and normal BMI groups among womenwith normal baseline FSH.CONCLUSION: We report for the first time a negative association be-tween BMI and serum AMH levels among women with elevated baselineFSH. We postulate that obesity has an adverse effect on ovarian reserveindependent of age. Further studies are needed to understand the mech-anisms of excess weight induced reduction in ovarian function.P-17 Tuesday, October 26, 2010OVARIAN RESERVE ASSESMENT IN PATIENTS WITH MULTIPLESCLEROSIS. A. P. Cil, A. Leventoglu, M. Sonmezer, A. Uzdogan,Z. B. Guler, K. Oktay. OB-GYN, Kirikkale University, Kirikkale, Turkey;Neurology, Ufuk University, Ankara, Turkey; OB-GYN, Ankara University,Ankara, Turkey; Biochemistry, Hacettepe University, Ankara, Turkey; OB-GYN, Kirikkale University, Kirikkale, Turkey; OB-GYN, Institute for Fertil-ity Preservation, Valhalla, NY.OBJECTIVE: Multiple sclerosis (MS) is the most common disablingcentral nervous system disease of young adults with a female-to-male ratioof 3-2:1, majority (80%) being diagnosed between the ages of 20 and 45years. Recently, the most popular treatment used for these patients are im-munomodulating drugs (IMD). There is limited data about fertility andovarian reserve in MS patients using IMD. In the current study, we soughtto determine whether ovarian reserve is impaired in women with MS re-ceiving IMD.DESIGN: Prospective controlled.MATERIALS AND METHODS: Seventeen women with MS and 28 age-matched regularly menstruating controls were prospectively enrolled. Sub-jects were examined on cycle days 2-5 to evaluate ovarian volume andAFC by ultrasound. On the same day, serum AMH, FSH, LH, and E2 levelswere measured. All patients had been taking IMD for a mean duration of 44.4 33.3 months, at the time of study inclusion.RESULTS: MS patients and controls had comparable mean BMI andage at the study inclusion. None of the ovarian reserve markers showeda significant difference between MS patients and the controls (table-1).AMH levels correlated positively with mean ovarian volume and AFC(r ¼ 0.559; p < 0.001 and r ¼ 0.696; p < 0.001), whereas it corre-lated negatively with FSH and age (r ¼ -0.606; p<0.001, r ¼ -.436;p¼0.003).Comparison of demographic, hormonal and sonographic parameters of patientswith MS and controlsVolMS (n¼17). 94., No. 4, SupControls(n¼28)plement, Septembep valueAge (y) 34.2  6.1 33.4  6.1 0.573BMI (kg/m2) 25.4  4.9 23.9  4.8 0.264AMH (ng/ml) 3.3  2.7 3.4  2.8 0.851FSH (mIU/mL) 7.9  3.5 7.9  2.7 0.576LH (mIU/mL) 8.1  8.2 5.5  1.6 0.385E2 (pg/mL) 39.1  11.8 39.2  16.3 0.843Mean AFC (2-9 mm) 9.2  5.5 11.6  6.1 0.200Mean ovarian volume(cm3)7.0  3.2 9.3  3.7 0.053CONCLUSION: Long term therapy with IMD does not appear to impairovarian reserve in women with MS.P-18 Tuesday, October 26, 2010SERUM MARKERS OF OVARIAN AGING ARE ASSOCIATEDWITH NATURAL FERTILITY. A. Z. Steiner, A. H. Herring,S. Hoberman, F. Z. Stanczyk, D. D. Baird. Obstetrics and Gynecology, Uni-versity of North Carolina, Chapel Hill, NC; Biostatistics, University of NorthCarolina, Chapel Hill, NC; Obstetrics and Gynecology, University of South-ern California, Los Angeles, CA; Epidemiology Branch, NIEHS/NIH,Research Triangle Park, NC.OBJECTIVE: Measures of ovarian aging are used as tests of fertility. Wesought to generate estimates of the associations between early follicularphase follicle stimulating hormone (FSH), antimullerian hormone(AMH), inhibin B, and estradiol (E2) and fecundability in the generalpopulation.DESIGN: Prospective time-to-pregnancy study.MATERIALS AND METHODS: Women, 30-44 years old, with no historyof infertility, who were trying to conceive for less than 3 months, providedearly follicular phase serum (N¼99). They were followed until pregnancyor for 6 months. While trying to conceive, women conducted standardizedpregnancy testing and kept a diary recording bleeding and intercourse. Serumwas analyzed for E2, FSH, AMH, and inhibin B. To adjust for patterns of in-tercourse, diary data were used to calculate day-specific probabilities of con-ception.RESULTS: Sixty-four percent of women had conceived after 6 monthsof follow up. After adjusting for age, low AMH and high FSH were re-spectively associated with a 62% and 56% lower odds of conceivinggiven an act of intercourse on a fertile day (Table). Inhibin B and E2showed no significant association with day-specific probabilities ofconception.r 2010

Ovarian reserve assesment in patients withmultiple sclerosis

Annual Meeting of the American-Society-for-Reproductive-Medicine (ASRM 2010) -- OCT 23-27, 2010 -- Denver, COWOS: 000281441000333…Amer Soc Reproductive Me

Cil, A. P.

Leventoglu, A.

Sonmezer, M.

Uzdogan, A.

Guler, Z. B.

Oktay, K.

Kırıkkale Üniversitesi Akademik Arşiv Sistemi

OVARIAN RESERVE ASSESMENT IN PATIENTS WITHMULTIPLE SCLEROSIS.

http://acikerisim.ufuk.edu.tr/xmlui/bitstream/20.500.14065/3248/1/OVARIAN%20RESERVE%20ASSESMENT%20IN%20PATIENTS%20WITH%20MULTIPLE.pdf

Ovarian reserve assesment in patients withmultiple sclerosis

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