Mastalgia is a common issue that disrupts the reproductive life of women. There is no accepted organic etiology and no definite cure for mastalgia. Mastalgia influences the general quality of life which is related to psychological variables. The present study administrated to determine the effect of yogic practice on breast pain, anxiety, stress, and biochemical profile with cyclical mastalgia girls. Forty females having breast pain past 6 months were recruited for this study and randomly assign into two groups (yoga group and control group) with the age range of 20–30 years (23.52 ± 2.28). Sixty days of yoga intervention were given to the yoga group. Breast pain shown a significant reduction in yoga group in compare to control group (P < 0.001). Similarly, yoga group found a significant reduction in anxiety (P < 0.01) and stress (P < 0.01) as compare to control group. There were no significant changes which were found in progesterone (P > 0.05) and estrogen (P > 0.05) in both groups but the magnitude of change was high in progesterone level in the yoga group. This study suggests that 2 months of yoga practice reduce the breast pain, anxiety, and stress in cyclical mastalgia girls
