ABSTRACT: A novel extended release Alfuzosin hydrochloride (HCL) tablet formulation which possesses a unique combination of floatation and bioadhesion for prolonged residence in the stomach has been developed. Alfuzosin HCl is a selective α-adrenergic antagonist used against benign prostatic hyperplasia (BPH). The usual dose of immediate release Alfuzosin HCl tablet is 2.5mg thrice a day. Therefore, there is need to formulate once daily sustained release tablet of Alfuzosin HCl which is convenient for older patients. In this work floating and/or bioadhesive tablets were prepared by direct compression method which is economical and easy to scale up. Polymers like Hydroxy propyl methyl cellulose (HPMC K100M), Carbopol 934P, Sodium carboxyl methyl cellulose (Na CMC) & Sodium bicarbonate in different ratios. Formulations were evaluated for in vitro drug release profile, swelling characteristics and in vitro bioadhesion property.  Sustained drug release with floating duration up to 24hrs and high bioadhesive strength was observed in case of Optimized formulation. Key-words: Alfuzosin, Gastro retentive, Optimized, Controlled release
