The most important effect of dihydroergotamine is venoconstriction, but certain metabolic effects and changes in vessel prostanoid activity have also been suggested. In this study endothelial cell production of 6-keto PGF 1α and TxB 2 was quantitated in vitro. No evidence of altered prostanoid production was noted after incubation with dihydroergotamine (exposure ranging from 5×10 −3 to 5×10 −7 g/l). Similarly, no effect of dihydroergotamine on the growth rates of endothelial cells or smooth muscle cells in vitro was documented.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42798/1/18_2005_Article_BF01941713.pd