Injection of a water-soluble dermal extract into adult rats resulted in depression of DNA synthesis in granulation tissue at 3 different sites of injury, but not in epithelium. This suggests that connective tissue proliferation may be controlled in part by a chalone-like mechanism.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42665/1/18_2005_Article_BF01937006.pd