Objectives: Urinary tract infections (UTIs) are one of the most common bacterial infections affecting humans throughout their life span. There is paucity of literature in relation to pathogenesis of UTIs caused by Pseudomonas aeruginosa. Therefore the current study was conducted to know the antibiotic sensitivity pattern of P. aeruginosa isolated from UTIs from our hospital.Methods: The study was carried out over a period of 3 years from January 2010 to December 2012. Urine specimens from both outpatients and inpatients of our hospital were processed. Urine samples which yielded the growth of Pseudomonas aeruginosa were included in the study Results: Among females, frequency of UTI was more among 21-50 years age groups and among males elderly patients were more commonly affected. The most active antimicrobial agent against Pseudomonas aeruginosa isolates were piperacillin-tazobactum (54% sensitive), closely followed by Cefoparazone –salbactam (48%).Conclusion: This study stresses the importance of prior knowledge of the sensitivity pattern of the pathogen. Treatment should be given only after culture and sensitivity has been performed which will prevent the misuse of antibiotics and reduce the development of drug resistance among bacteriaÂ