CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
ANTIMICROBIAL, ANTIOXIDANT, CYTOTOXIC ACTIVITIES AND PHYTOCHEMICAL ASSESSMENT OF COLA ACUMINATA USED IN BENIN
Authors
Adolphe Adjanohoun
Nafan Diarrassouba
+7 more
Joachim D. Gbenou
Farid Baba Moussa
Lamine Baba Moussa
PACOME A. NOUMAVO
Durand Dah Nouvlessounon
Hubert Adoukonou Sagbadja
Haziz Sina
Publication date
1 June 2015
Publisher
'Innovare Academic Sciences Pvt Ltd'
Abstract
Objective: The aim of this study was to make a phytochemical screening and measure some biological activities of Cola acuminata's seeds and leaves extracts.Methods: The secondary metabolite was detected by the method based on coloring and precipitation differential reactions. The antibacterial and antifungal activities were assessed in vitro by the macrodillution and solid medium agar diffusion method. 2,2-diphényl-1-picrylhydrazyl (DPPH) and 2,2'-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) methods were used to evaluate the antioxidant activity of the tested extracts of which larval cytotoxicity was studied.Results: Our data revealed that the seeds contain more polyphenols than the leaves. The seeds extracts displayed a good antibacterial activity against both reference strains and food Staphylococcus strains. The inhibition diameters varied from 7±2.82 to 21.5±4.94 mm. The smallest Minimum Inhibitory Concentrations (MIC) on the food strains (0.08 mg/ml) is twice less than the reference strains one (0.15 mg/ml), this observation is contrary to the Minimum Bactericidal concentrations (MBC). Susceptibility of fungal strains varies according to the extracts (p = 0.0016). The seeds ethyl acetate extracts had the best antioxidant activity with DPPH and ABTS methods. The Lethal Doses (LD50) showed that no extract was toxic.Conclusion: Cola acuminata seeds are richer than the leaves in compounds with biological activities. These two organs have interesting antimicrobial, antifungal and antioxidant activity variables depending to the extracts. The seeds have better biological activity than the leaves.Â
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Innovare Academic Sciences: E-Journals
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ojs2.innovareacacdemics.in...
Last time updated on 12/12/2021