Objective: The main objective of the research was to formulate directly compressible fast disintegrating tablets of glimepiride by using different super disintegrants such as crospovidone, croscarmellose sodium, sodium starch glycolate and L-HPC in various concentrations.Methods: The prepared tablets were evaluated for various tablet properties like weight variation, thickness, hardness, friability, taste, drug content, in vitro and in vivo disintegration time, and in vitro drug release, in vivo dynamic studies. Other parameters such as wetting time, water absorption ratio, and drug-excipient compatibility were also evaluated.Results: The disintegration time of the optimized fast disintegrating tablet formulation was observed to be 12 s in vitro and 19.80 s in vivo. The correlation was observed between disintegration time and ‘R' for each of the four super disintegrants at the concentrations studied. Considering the ‘R' values and disintegration time, croscarmellose sodium was significantly superior compared to the other super disintegrants tested. Drug release was faster from formulations containing 25% croscarmellose sodium compared to the pure drug and without super disintegrant glimepiride tablet. FTIR studies did not indicate any excipient incompatibility, either during mixing or after compression. Optimized formulation exhibited good results in the decrease in blood glucose in rats when compared to the pure drug and marketed product.Conclusion: Form the results if this study it can be concluded that prepared optimized fast disintegrating tablets of glimepiride are the better option to treat diabetes.Keywords: Superdisintegrants, Fast disintegrating tablets, Disintegration time, Water absorption ratio, Wetting time, Dissolution, Dynamic studie
