Objective: This study evaluates the hypoglycemic effect of COQ10 and Vitamin E are determined using STZ induced diabetic rats.Methods: Rats selected for this study were divided into five groups of ten rats each as follows: first group Normal control rats, the second is considered as diabetic groups, injected intraperitoneal with a single dose of STZ (60 mg/kg B. wt). the third group Diabetic rats orally administered glibenclamide drug 10 mg/kg B. wt daily for 30 d 4th. And 5th groups were treated orally glibenclamide combined with vitamin E (2% concentration added to the normal basal diet), or coenzyme Q10 at the dose of 10 mg/kg i. p. daily for 30 consecutive days in addition histological examinations of liver, kidney and brain were carried out to confirm the biochemical changes of the diabetic group of rats.Results: All liver enzymes activities alanine and aspartate transferases and alkaline phosphatase (AST, ALT and ALP respectively), kidney function tests; creatinine and total urea, inflammatory biomarkers; CRP, IL-10 and TNF-α. Neurotransmitters; acetylcholine and acetylcholine esterase were enhanced with the highest degree in groups treated with COQ10 or vitamin E in addition to glibenclamide dug, almost restore the normal histological architecture of liver, kidney and brain.Conclusion: Orally supplemented glibenclamide with coenzyme Q10 or vitamin E showing significantly reduced blood glucose levels in STZ induced diabetic rats. It also showed hypolipidemia as well as hepatoprotective effects, enhance histological feature of liver, kidney and brain.Â
