Aslam, T.

Berger, M.

Crabb, D. P.

Denniston, A. K.

Finger, R.

Holz, F. G.

Keane, P. A.

Liu, X.

Montesano, G.

Neuber, F.

Ometto, G.

Pleyer, U.

Pohlmann, D.

Terheyden, J. H.

Wintergerst, M. W. M.

City Research Online

              City, University of London Institutional RepositoryCitation: Pohlmann, D., Terheyden, J. H., Berger, M., Ometto, G., Montesano, G., Neuber, F., Wintergerst, M. W. M., Aslam, T., Liu, X., Holz, F. G., et al (2020). OCT-based automated vitreous inflammation score: a promising biomarker in dexamethasone implant treated uveitis patients. Investigative Ophthalmology & Visual Science (IOVS), 61(7), ISSN 0146-0404 This is the published version of the paper. This version of the publication may differ from the final published version. Permanent repository link:  https://openaccess.city.ac.uk/id/eprint/27394/Link to published version: Copyright: City Research Online aims to make research outputs of City, University of London available to a wider audience. Copyright and Moral Rights remain with the author(s) and/or copyright holders. URLs from City Research Online may be freely distributed and linked to.Reuse: Copies of full items can be used for personal research or study, educational, or not-for-profit purposes without prior permission or charge. Provided that the authors, title and full bibliographic details are credited, a hyperlink and/or URL is given for the original metadata page and the content is not changed in any way. City Research OnlineCity Research Online:            http://openaccess.city.ac.uk/            publications@city.ac.uk1/2OCT-based automated vitreous inflammation score: apromising biomarker in dexamethasone implant treateduveitis patients | IOVSiovs.arvojournals.org/article.aspxARVO Annual Meeting Abstract  |   June 2020OCT-based automated vitreous inflammation score: a promising biomarker indexamethasone implant treated uveitis patientsInvestigative Ophthalmology & Visual Science June 2020, Vol.61, 3245. doi:AbstractPurpose : To objectively detect and evaluate vitreous inflammation before and afterdexamethasone implant in patients with uveitis by using a recently developed opticalcoherence tomography (OCT)-based algorithm.Methods :In this multicenter, retrospective, cross-sectional study, 302 eyes of 223 uveitis patientswere included. Clinical and OCT data (Spectralis; Heidelberg Engineering Inc) of allpatients were collected. The inflammation score was obtained using an availableautomated OCT-based algorithm.  Data of pre and post dexamethasone implantationwere compared using a random effects model.Montesano, G., Way, C. M., Ometto, G., Ibrahim, H., Jones, P. R., Carmichael, R., Liu, X.,Aslam, T., Keane, P. A., Crabb, D. P. & Denniston, A. K. (2018). Optimizing OCTacquisition parameters for assessments of vitreous haze for application in uveitis.Scientific Reports, 8, 1648. doi: 10.1038/s41598-018-20092-yResults : Patients with cystoid macular edema in uveitis anterior (n=18 eyes),intermediate (n=106 eyes), posterior (n=153 eyes), and panuveitis (n=25 eyes) weretreated with a dexamethasone implant. The mean of age was 61 years +/- 15 years and arange of 22 to 88 years. We registered 277 follow-up visits at 1 month (up to 2 monthsafter injection) and 265 follow-up visits at 3 months (>2 months to 4 months). The meaninflammation score at baseline was 0.135, and changed significantly to 0.077 (p<0.0001)1-2 months and to 0.079 (p<0.0001) 3 months after dexamethasone injection.Correlations with clinical ratings of intraocular inflammation are currently evaluated.Conclusions : Automated OCT-based objective quantification of vitreous inflammationcaptures the expected decrease in vitreous inflammation following intravitrealdexamethasone implant. Thus, the automated OCT-based quantification of vitreousinflammation may be a promising alternative and a potentially relevant biomarkercompared to current subjective clinical estimates of vitreous inflammation in uveitis.This is a 2020 ARVO Annual Meeting abstract.112/2This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.AdvertisementCopyright © 2015 Association for Research in Vision and Ophthalmology.  

OCT-based automated vitreous inflammation score: a promising biomarker in dexamethasone implant treated uveitis patients

https://openaccess.city.ac.uk/id/eprint/27394/1/iovs.arvojournals.org-OCT-based%20automated%20vitreous%20inflammation%20score%20a%20promising%20biomarker%20in%20dexamethasone%20implant%20treate.pdf

OCT-based automated vitreous inflammation score: a promising biomarker in dexamethasone implant treated uveitis patients

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