We report a compact lab-on-chip design of a Mach-Zehnder interferometer (MZI) incorporating a novel metal strip loaded horizontal slot hybrid plasmonic waveguide (HSHPW) in the sensing arm and a dielectric horizontal slot (DHS) waveguide in the reference arm. The HSHPW is optimized to confine a high ∼60% and ∼82% evanescent optical field in the low index dielectric slot and an active sensing region, respectively which enhance the device sensitivity with a comparative lower propagation loss than a typical plasmonic waveguide. We report here a single MZI configuration which not only exhibits an excellent temperature sensitivity of 243.9 pm/°C but also liquid concentration sensitivity of 437.3 nm/RIU for a 40 μm long HSHPW. To mitigate loss arising from each section such as butt coupling and plasmonic modal losses, the HSHPW has been optimized by incorporating an asymmetric power splitter which shows a considerable improvement in the fringe visibility and device insertion loss. Thus, the proposed single MZI design shows an excellent response to the temperature and liquid concentration sensing with a maximum total loss and extinction ratio of 2.56 dB and>25 dB, respectively. A much simpler CMOS friendly compact design is also found to have a great robustness to the fabrication tolerances
