Haematological and clinical profile in Nigerian sickle cell disease patients with and without chronic kidney disease

Abstract

Background: Sickle cell disease (SCD) has adverse effects on the kidneys which impact on clinical outcome.Objectives: To study and compare some clinical and haematological profiles in SCD patients, with and without chronic kidney disease (CKD).Methods: Prospectively, 92 SCD patients were investigated and stratified into those with CKD (creatinine clearance ≤60ml/min) and those without (creatinine clearance≥60ml/min). Socio-demographic data, clinical and haematological parameters were documented and compared in the two groups as well as with gender stratification, using the student’s t-test.Results: The crises frequency and transfusion history (in males) together with the corrected reticulocyte count (in females) were significantly different in SCD patients with CKD, compared to those without (p values<0.05).Conclusion: Kidney disease significantly influences some clinical and haematological parameters in patients with SCD, which could impact on survival.Keywords: Corrected reticulocyte count, transfusion history, vaso-occlusive crise