Ghana discovered commercial oil and gas in 2007, and, subsequently, commenced production in the last quarter of 2010. In the light of the potential economic boost that will accompany petroleum production, its discovery was welcome news for Ghanaians. However, oil exploration and production involve several activities that can have detrimental impacts on the ecosystem. In this paper, the potential sources of pollution in the upstream sector of the oil and gas industry and their effects on the environment are discussed. Also discussed are existing national environmental management legislations in the extractive industry, and the implementation and enforcement challenges these regulations face. Strategies to curtail the effects of oil and gas development on the ecosystem are also put forward. These include the need for government to formulate petroleum industry-specific environmental protection guidelines and appropriate regulatory frameworks. Such regulations in managing the environment should employ an integrated approach involving (i) prescription of environmental codes and setting of standards by government to be met by operators, and (ii) the need for oil companies to develop environmental management system (EMS) to ensure that they operate within the environmental standards for the industry. Administrative and institutional restructuring and reforms, as well as the provision of the necessary financial and human resources for the various environmental agencies, should be encouraged to ensure effective implementation, enforcement and monitoring