Context: Appendectomy is generally conducted as open or by laparoscopic surgical techniques under general anesthesia.Aims: This study aims to compare the anesthetic costs of the patients, who underwent open or laparoscopicappendectomy under general anesthesia.Settings and Design: The design is retrospective and records of 379 patients who underwent open or laparoscopicappendectomy under general anesthesia, falling under the category of I‑III risk group according to the American Societyof Anesthesiologists (ASA) classification between the years 2011 and 2013, and aged 18-77.Subjects and Methods: Open (Group I) or laparoscopic (Group II) appendectomy operation under general anesthesiawere evaluated retrospectively by utilizing hospital automation and anesthesia observation records. This study evaluatedthe anesthesia time of the patients and total costs (Turkish Lira ₺, US dollar )ofanestheticagentsused(induction,maintenance),necessarymedicalmaterials(connectingline,endotrachealtube,airway,humidifier,branule,aspirationprobe),andintravenouslyadministeredfluidswereevaluated.StatisticalAnalysisUsed:WeusedStatisticalPackagefortheSocialSciencessoftware(SPSSversion17.0)forstatisticalanalysis.Results:Ofthepatients,237weremales(62.53) in Group I and 83.09 ± 26.85₺ (41.29 ± 13.34$) inGroup II (P > 0.05). A correlation was observed between cost and operation times (P = 0.002, r = 0.158).Conclusions: Although a statistical difference was not established in this study in terms of time and costs inappendectomy operations conducted as open and laparoscopically, changes may occur in time in market conditionsof drugs, patent rights, legal regulations, and prices. Therefore, we believe that it would be beneficial to update andrevise cost analyses from time to time.Keywords: Cost, cost comparison laparoscopic appendectomy, open appendectom