BACKGROUND Financial toxicity (FT) is a well-established side-effect of the high costs associated with cancer care. In recent years, studies have suggested that a significant proportion of those with atherosclerotic cardiovascular disease (ASCVD) experience FT and its consequences. OBJECTIVES This study aimed to compare FT for individuals with neither ASCVD nor cancer, ASCVD only, cancer only, and both ASCVD and cancer. METHODS From the National Health Interview Survey, we identified adults with self-reported ASCVD and/or cancer between 2013 and 2018, stratifying results by nonelderly (age \u3c65 \u3eyears) and elderly (age 65years).WedefinedFTifanyofthefollowingwerepresent:anydifficultypayingmedicalbills,highfinancialdistress,cost−relatedmedicationnonadherence,foodinsecurity,and/orforegone/delayedcareduetocost.RESULTSTheprevalenceofFTwashigheramongthosewithASCVDwhencomparedwithcancer(543 of these factors was significantly higher among those with ASCVD and those with both ASCVD and cancer when compared with those with cancer (23% vs. 30% vs. 13%, respectively; p\u3c 0.001). These results remained similar in the elderly population. CONCLUSIONS Our study highlights that FT is greater among patients with ASCVD compared with those with cancer, with the highest burden among those with both conditions