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The role of hypoxia in the tumor microenvironment and development of cancer stem cell: a novel approach to developing treatment
Authors
M. Ahmadlou
A. Emami Nejad
+11 more
M. Esparvarinha
S. Haghjooy Javanmard
M. Manian
S. Najafgholian
R. Nedaeinia
A. Rostami
B. Sadeghi
R. Salehi
S. Shojaeifar
A. Sistani
M. Taherian
Publication date
1 January 2021
Publisher
Abstract
Hypoxia is a common feature of solid tumors, and develops because of the rapid growth of the tumor that outstrips the oxygen supply, and impaired blood flow due to the formation of abnormal blood vessels supplying the tumor. It has been reported that tumor hypoxia can: activate angiogenesis, thereby enhancing invasiveness and risk of metastasis; increase survival of tumor, as well as suppress anti-tumor immunity and hamper the therapeutic response. Hypoxia mediates these effects by several potential mechanisms: altering gene expression, the activation of oncogenes, inactivation of suppressor genes, reducing genomic stability and clonal selection. We have reviewed the effects of hypoxia on tumor biology and the possible strategiesto manage the hypoxic tumor microenvironment (TME), highlighting the potential use of cancer stem cells in tumor treatment. © 2021, The Author(s)
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:38970
Last time updated on 11/10/2021