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Expression analysis of apoptosis-related genes in bladder cancer patients
Authors
M. Afsharpad
S. Ghafouri-Fard
+6 more
M.H. Modarressi
T. Moharrami
L. Nekoohesh
V.K. Oskooei
N. Samadaian
F. Yazarlou
Publication date
1 January 2018
Publisher
Abstract
Background: Bladder cancer (BC) is a frequent cancer with high morbidity and mortality. Method: We assessed expression of NMP22, BAG3, BCL2 and BAX in BC samples, adjacent non-neoplastic tissues (ANNTs), urinary cell pellets (UCP) of the same patients and non-malignant conditions (NM). Results: NMP22 was up-regulated in tumoral tissues compared with ANNTs and in UCP of BC patients compared with UCP of NM. BCL2 and BAX were down-regulated in BC tissues compared with ANNTs. BAG3 and BAX were down-regulated in UCP of BC compared with NM. The combination of all four genes had 100 sensitivity and specificity for detection of BC in urine. Conclusion: Expression analysis of these genes in tumor or urine is a tool for detection of BC. © 201
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eprints Iran University of Medical Sciences
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oai:eprints.iums.ac.ir:6154
Last time updated on 10/10/2019