Ayurveda, the Indian system of medicine, advocates about different types of Chikitsa. Daivavyapashraya Chikitsa is one of the treatment approaches concerned with Spiritual way of treatment. It includes so many approaches, amongst all Mantra Chikitsa is described in Ayurveda at various places as a potent approach. It is discussed for both the healthy and unhealthy conditions. Mantra comes from Sanskrit word which means sacred message or text, spell. Basically Mantra is pure thought from a pure heart, which acts as an inspirational believe. When Mantra is constantly repeated awakens the consciousness-chit or Chaithanya. Mantra Chikitsa is one among the Daivavyapashraya Chikitsa highlights the importance of concept of Mantra. In Atharva Veda and Kaushikasutra, the two most ancient and authentic sources of Daivavyapashraya. Mantra Chikitsa is mainly used for both preventive and curative aspect. It is also used for the enhancement of the Gunas of Aushadhi. Effect of Mantra is described as Prabhavajanya action. Prabhava means the specific and characteristic action of substances, it is called as Acintya. Mantra Chikitsa cure the Karmaja Vyadhi and Agantuja Vyadhi. In the Vedic period, Daivavyapashraya Chikitsa was followed in various rituals. These rituals were used to get rid of various Karmaja Vayadhi and Agantuj Vyadhi. This review paper will focus upon the concept of Mantra Chikitsa to make it more comprehensive and practicable