Background: Chronic kidney disease is a spectrum of different pathophysiologic processes associated with abnormal kidney function and a progressive decline in glomerular filtration rate. Globally it is the 12th cause of death and 17th cause of disability. Clinically this condition can be correlated to madumeha and mutrakshaya. Methodology: A 60yr old female patient with uncontrolled type 2 diabetes mellitus and chronic kidney disease (stage 4) was advised hemo-dialysis, which she was not willing to undergo, attended out patient department of Kayachikitsa, at SDM College of Ayurveda & Hospital, Hassan. Patient was treated with shamanaaushadi, Mustadiyapana basti, and with specific pathyaahara. Assessment was done before and after treatment with serum creatinine, eGFR and oedema grade. Result: After 9 days of treatment, there was significant change in the bilateral pedal oedema, urine output, general condition and also reduction in the serum creatinine. Conclusion: Chronic kidney disease was effectively managed by treatment modalities mentioned in Ayurveda after proper assessment of the dosha, dushya and vyadhi avasta
