Infertility is an increasing condition in society which has become a challenge to the gynaecologist. Based on the census reports of India 2001, 1991, 1981 researchers show that childlessness has increased by 50% since 1981. The increase may be due to many reasons, as sexually transmitted infections, coping with stress, the way of living, job pressure, postponing parenthood, galloping urbanization, obesity etc. Vandhya Stree is either due to Beeja Dosha or other causes where she can be treated and made to conceive. Vandhyatva is a condition which occurs as a complication of various diseases, different Yonivyapats, Jatharagnis, Artavadushtis, Beejadosha, Mithyaachara, Daiva are various contributory factors for Vandhya. Many treatments have been available with different success rates. They include fertility drugs, intrauterine insemination (IUI), in vitro sperm injection (ICSI), donor insemination (DI), egg (or embryo) donation and surrogacy. long standing infections of vagina or urinary system, UTI, TORCH infections contribute to non conception due to compromised immune system. Atimaithuna in Baalaavashtha is explained as one of the causes for Yonivyapats, treating the Yonivyapat and reducing infection enhances conception. This theory was followed in this case to achieve conception. Presenting such a case with long standing infertility and infection treated successfully with Ayurvedic medicine and achieved conception