Introduction: Infertility is the clinical entity where couple fail to conceive even after one year of regular unprotected sexual activity. Many factors are responsible for infertility like ovulation defects, spermatogenic failure, parental age, obesity, anatomical defects, infections, also with specific karyotype and genotype. Materials and Methods: Data was collected from Classical references and modern textual references to show how Ayurveda explains beautifully about the infertility, genetic cause for it. Results: Effort are made to explain genetic theory according to Ayurveda in the context of Infertility Discussion: To have a healthy individual constitution impact of certain factors are very essential, which includes healthy reproductive organs of both male and female, healthy sperm and ovum, dietic regimen, Prakruti of couple, seasonal effect, Panchamahabhoota and Shadbhavas. Impact of Doshas on these will have vital role in formation of genetic code and reproductive capacity of individual. Hence all the above factors may be said as factors responsible for genetic modification influencing the fertility in Ayurveda. This knowledge is highly essential and need of the day for welfare of better society with good progeny through means of Ayurveda