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Design, synthesis, and analysis of conformationally constrained nucleic acids
Authors
Basu
Beal
+106 more
Beaudry
Been
Bevilacqua
Bevilacqua
Burke
Caprara
Cate
Cate
Cate
Cech
Cech
Cech
Celander
Chanfreau
Chowrira
Christian
Christian
Conrad
Costa
Costa
Damberger
Deeney
Doherty
Doudna
Eckstein
Engel
Fareed
Gaur
Gautheret
Gautheret
Gish
Gutell
Gutell
Hardt
Harris
Harris
Harris
Herr
Herschlag
Herschlag
Huang
Hur
Kleppe
Knitt
Kuimelis
Latham
Litt
Mei
Michel
Moore
Moore
Moore
Moser
Murphy
Murray
Narlikar
Nolan
Nolan
Noller
Ortoleva-Donnelly
Ortoleva-Donnelly
Pearson
Peattie
Peattie
Pecoraro
Pyle
Pyle
Pyle
Pyle
Pyle
Pyle
Riddle
Rife
Roth
Ruffner
Saenger
Sano
Saville
Scaringe
Sigler
Sousa
Stern
Strobel
Strobel
Strobel
Strobel
Strobel
Strobel
Strobel
Szewczak
Tanner
Tanner
Tanner
Thomson
Turner
Uesugi
Usman
Usman
von Ahsen
Wang
Waring
Waring
Whoriskey
Woese
Woodson
Yu
Publication date
1 January 1998
Publisher
'Wiley'
Doi
Abstract
In this review I discuss straightforward and general methods to modify nucleic acid structure with disulfide cross-links. A motivating factor in developing this chemistry was the notion that disulfide bonds would be excellent tools to probe the structure, dynamics, thermodynamics, folding, and function of DNA and RNA, much in the way that cystine cross-links have been used to study proteins. The chemistry described has been used to synthesize disulfide cross-linked hairpins and duplexes, higher order structures like triplexes, nonground-state conformations, and tRNAs. Since the cross-links form quantitatively by mild air oxidation and do not perturb either secondary or tertiary structure, this modification should prove quite useful for the study of nucleic acids. © 1998 John Wiley & Sons, Inc. Biopoly 48: 83–96, 1998Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/37876/1/8_ftp.pd
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Last time updated on 25/05/2012
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Last time updated on 24/08/2020