Loran-C signals along and in the Lower St. Lawrence River, namely between Québec City and the Gaspesia Peninsula on the south shore, between Québec City and Havre-Saint-Pierre on the North Shore, and between Québec City and Anticosti Island in the river, were analyzed using a mobile Loran-C coverage validation and calibration system consisting of analog and digital Loran-C receivers, differential GPS and data logging systems. The road measurements were made successively during February-March and July-August 1991 to analyse seasonal effects. The signals received from the East Coast Canada Chain (5930M, X, Y, Z) and the Northeast U.S. Chain (9960M, W, X) are discussed herein. The Field Strength and Signal to Noise Ratio measurements are compared with predicted values using various models for conductivity and atmospheric noise. The Time Difference (TD) measurements are first compared between forward and reverse runs along the road profiles to ascertain the quality and reliability of the system utilized. The differences between Winter and Summer TD measurements are then analyzed. A relatively small but significant seasonal effect is found. The GPS-derived TD distortions are compared with those derived using various models for the combined effect of the primary, secondary and additional secondary phase lags. The differences between measured and modeled distortions reaches several jis. The effect of these differences on Loran-C positions is found to reach several hundred metres in many cases. Conclusions related to the results presented herein are made, together with recommendations pertaining to the use of these results and future investigations