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Regulation of CDK9 activity by phosphorylation and dephosphorylation
Authors
Denitra Breuer
Sergei Nekhai
Michael Petukhov
Publication date
17 February 2014
Publisher
Digital Howard @ Howard University
Abstract
HIV-1 transcription is regulated by CDK9/cyclin T1, which, unlike a typical cell cycle-dependent kinase, is regulated by associating with 7SK small nuclear ribonuclear protein complex (snRNP). While the protein components of this complex are well studied, the mechanism of the complex formation is still not fully understood. The association of CDK9/cyclin T1 with 7SK snRNP is, in part, regulated by a reversible CDK9 phosphorylation. Here, we present a comprehensive review of the kinases and phosphatases involved in CDK9 phosphorylation and discuss their role in regulation of HIV-1 replication and potential for being targeted for drug development. We propose a novel pathway of HIV-1 transcription regulation via CDK9 Ser-90 phosphorylation by CDK2 and CDK9 Ser-175 dephosphorylation by protein phosphatase-1. © 2014 Sergei Nekhai et al
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Howard University: Digital Howard
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Last time updated on 16/12/2021