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Models of natural mutations including site heterogeneity
Authors
Borgstahl
Borgstahl
+22 more
Brünger
Cusack
Fukami-Kobayashi
Gilbert
Go
Go
Ikura
Inaba
Jancarik
Nagai
Nagai
Nagai
Navaza
Otwinowski
Rossmann
Sakabe
Shirai
Wada
Wakasugi
Wakasugi
Yanagawa
Yaoi
Publication date
1 January 1998
Publisher
'Wiley'
Doi
Abstract
New computational models of natural site mutations are developed that account for the different selective pressures acting on different locations in the protein. The number of adjustable parameters is greatly reduced by basing the models on the underlying physical-chemical properties of the amino acids. This allows us to use our method on small data sets built of specific protein types. We demonstrate that with this approach we can represent the evolutionary patterns in HIV envelope proteins far better than with more traditional methods. Proteins 32:289–295, 1998. © 1998 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/38528/1/4_ftp.pd
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oai:deepblue.lib.umich.edu:202...
Last time updated on 25/05/2012
Archivio della Ricerca - Università della Basilicata
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oai:iris.unibas.it:11563/3844
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Last time updated on 24/08/2020