Helicobacter pylori is considered to be the most common human bacteria in the pathogenesis of chronic gastritis and peptic ulcer diseases. gastric inflammation associated with the infiltration of various immune cells into the infected gastric mucosa . The immune and inflammatory response is ineffective, allowing lifelong bacterial persistence, the host immune response is unable to clear the infection and may actually contribute to the pathogenesis. The immunogen that injected to an animal may have a profound on the outer come of the immune responses. Four successive doses of heat killed H. pylori (HpHK) antigen was intravenous injected in rabbits at five days a part manner. HpHK antigen stimulate specific mucosal and systemic humoral and cellular immune response determined by raised in the immunoglobulin titers and concentrations, increased the concentrations of C3 and C4 which are the complement compartments with significant increased in the lymphoid cells that formed the rosette form , significant migration inhibition index , increased the concentrations of cytokines (IL-4 & IL-8) . HpHk antigen induced positive skin test tuberculin type delayed hypersensitivity, in addition to the histopathological changes at different body organ portions of the animals
