Effects of 1:1 Mixture of Anogeissus leiocarpus and Terminalia avicennioides Root Bark Extracts on Haematological Parameters, Liver and Kidney Function Indices of Male Rats

Abstract

Background: This study evaluated the effects of 1:1 mixture of aqueous root bark extracts of Anogeissus leiocarpus (DC) Guill & Perr (Combretaceae) and Terminalia avicennioides Guill & Perr (Combretaceae) in male rats. Methods: Male rats were orally administered a 1:1 mixture of both extracts (250, 500 and 1000 mg/kg body weight) for seven days. Liver and kidney function indices, haematological parameters and the levels of malondialdehyde were evaluated in the animals at 7 days post-administration of the mixture of the extracts. Results: Administration of mixture of the extract significantly (p0.05) altered. Conclusions: The present study revealed that the mixture caused functional toxicity of the liver and kidney of male rats without any evidence of haematotoxicity. The consumption of the 1:1 mixture of the plant extracts at 250, 500 and 1000 mg/kg body weight has some toxic implications in male rats