Comparison of Triglyceride Level between 24-28 week’s Gestation of Nondiabetic Women with and without Positive Diabetic Screening

Abstract

Objectives: To determine the difference in triglyceride levels (TG) between normal and abnormal glucose screening test but not diagnosed GDM in pregnant women.Materials and Methods: A prospective cohort study was conducted in 108 singleton pregnant women undergoing 50g glucose challenge test (50g GCT) at 24 to 28 weeks of gestation during June to November 2015. Eighty four in control group had normal 50g GCT and twenty four subjects with abnormal 50g GCT but negative on diagnostic test [100g oral glucose tolerance test (OGTT)] in study group. The TG and fasting blood sugar (FBS) were collected in both groups after 50g GCT for one week. Hypertriglyceridemia was defined as triglyceride level of 75th percentile or greater. The Receiver Operator Characteristic (ROC) curve was constructed to look for the cut-off level of TG which provide the best sensitivity and specificity of large for gestational age (LGA).Results: There was no significant difference in TG which was 188 and 189 mg/dl in control and study group respectively (p = 0.402). Hypertriglyceridemia was 237 mg/dl or greater. Incidence of hypertriglyceridemia was not different between groups (p = 0.508). The percentage of LGA in the study group was 29.2% while in the control group was 9.5% (p = 0.039). Using the cut-off TG > 183.5 mg/dl has a sensitivity of 60% and specificity of 44% for LGA detection. Conclusion: TG was not different between pregnant women with normal 50g GCT and those who had abnormal 50g GCT but negative on diagnostic test. The TG was not good indicator for LGA detection