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Effect of p53 overexpression on radiation sensitivity of human colon cancer cells
Authors
Abu-Shakra
Abu-Shakra
+18 more
Blomlie
Chuba
Cohen
Delattre
Duncan
Emami
Forman
Hall
Koh
Kyprianou
Laramore
Maughan
Richard
Richardson
Russell
Sandford
Stafford
Zar
Publication date
1 January 1997
Publisher
'Wiley'
Doi
Abstract
Substantial controversy surrounds our understanding of the effect of p53 status on radiation sensitivity. To assess directly the role of p53 expression on radiation sensitivity, we chose a conditional expression system using a temperature-sensitive murine p53 that permitted each cell line to act as its own control. We found that the conditional expression of wild type p53 induced cell death (both apoptotic and nonapoptotic), changes in cell cycle distribution (arrest in G 1 and G 2 , which resulted in a marked depletion of S-phase cells and an increase in the fraction of cells in G 2 ), and an increase in the radiation resistance of G 1 cells. These counterbalancing effects resulted in no significant effect on overall radiosensitivity. These findings demonstrate that wild type p53 function can produce a variety of effects that can modulate radiation sensitivity and may explain why p53 status alone has not been a strong predictor of radiosensitivity. Radiat. Oncol. Invest. 5:43–49, 1997. © 1997 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/35193/1/1_ftp.pd
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Last time updated on 25/05/2012
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