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Effects of estrogen agonists on amphetamine-stimulated striatal dopamine release
Authors
Alexander
Alexander
+38Β more
Baunez
Baunez
Bell
Berendse
Bevan
Bourassa
Canteras
Deniau
Deniau
Deniau
Fonnum
Groenewegen
Groenewegen
Groenewegen
Haber
Heimer
Kita
Kita
Kita
Kita
Kitai
Levy
Maurice
Montaron
Nakanishi
O'Donnell
Parent
Paxinos
Rinvik
Robledo
Rouzaire-Dubois
Shink
Smith
Smith
Van der Kooy
Zahm
Zahm
Zahm
Publication date
1 August 1998
Publisher
'Wiley'
Doi
Abstract
Based upon the observation that estrogen acts in the striatum to rapidly modulate dopamine (DA) neural transmission and DA-mediated behaviors, it has been postulated that these effects of estrogen are mediated by a specific, membrane-bound receptor mechanism. To further characterize the pharmacological specificity of the estrogen binding site, the present experiments examine effects of various estrogen agonists on amphetamine (AMPH)-induced DA release from striatal tissue of ovariectomized female rats, using a superfusion method. Catechol estrogens 4-, and 2-hydroxyestradiol, but not 2-methoxyestradiol, significantly enhance AMPH-induced striatal DA release. Estrogen metabolites, estrone and estriol, and the non-steroidal estrogen analog, diethylstilbestrol, are without effects. Estradiol conjugated to bovine serum albumin (BSA) mimics the effect of estradiol to enhance stimulated striatal DA release. These results indicate that the steroidal configuration and hydroxylation on the A-ring of estrogenic compounds may be important determinants of ligand binding to the putative estrogen binding site in the striatum. Furthermore, the effectiveness of the estradiol conjugated to BSA reinforces the idea of an external membrane-bound receptor binding site in the striatum. Synapse 29:379β391, 1998. Β© 1998 Wiley-Liss, Inc.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34982/1/10_ftp.pd
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