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The distribution of structures in evolving protein populations
Authors
Anachi
Bax
+53 more
Bella
Bella
Bella
Bhatnagar
Braunschweiler
Brodsky
Brodsky
Brown
Bächinger
Chan
Engel
Fan
Feng
Feng
Fields
Fields
Fietzek
Fietzek
Garnero
Goodman
Hoffmann
Holmgren
Huszar
Jeener
Kadler
Katz
King
Kramer
Kumar
Li
Liu
Long
Long
Marion
Mayo
Melacini
Melacini
Melacini
Piez
Piez
Piotto
Privalov
Rossi
Rossi
Shah
Torchia
van der Rest
Ward
Yang
Yang
Yu
Yu
Zanaboni
Publication date
1 January 2000
Publisher
'Wiley'
Doi
Abstract
Proteins exhibit a nonuniform distribution of structures. A number of models have been advanced to explain this observation by considering the distribution of designabilities, that is, the fraction of all sequences that could successfully fold into any particular structure. It has been postulated that more designable structures should be more common, although the exact nature of this relationship has not been addressed. We find that the nonuniform distribution of protein structures found in nature can be explained by the interplay of evolution and population dynamics with the designability distribution. The relative frequency of different structures has a greater-than-linear dependence on designability, making the distribution of observed protein structures more uneven than the distribution of designabilities. The distribution of structures is also affected by additional factors such as the topology of the sequence space and the similarity of other structures. © 2000 John Wiley & Sons, Inc. Biopoly 53: 1–8, 2000Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/34324/1/1_ftp.pd
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