METABOLIC STATUS OF VASCULAR ENDOTHELIUM IN PULMONARY TUBERCULOSIS PATIENTS WITH CONCURRENT DIABETES

Abstract

52 pulmonary tuberculosis patients with concurrent diabetes and 76 pulmonary tuberculosis patients without concurrent diabetes (control group) were examined. The state of vascular endothelium was evaluated by the content of nitrogen oxide (NO), endothelium-1 (E-1) and antigen of Willebrand factor (WF) in blood serum (plasma). Patients with concurrent condition had more significant changes in their metabolic status of vascular endothelium (endothelial dysfunction) compared to control group. It manifested through significant reduction of NO level, which is negatively correlated to the increase of glycosylated hemoglobin and the loss of the self-regulating ability of the endothelium cells. The latter was documented by development of the negative correlation between rates of NO and E-1 (in the comparison group the correlation was positive). Functional decompensation of vascular endothelium in pulmonary tuberculosis patients with concurrent diabetes was accompanied by the presence of endothelial destructive lesions, documented increase of  WF (in the majority of patients from the control group WF was within the upper limit of the referent rates). In 3 months of complex treatment of patients with concurrent pathology NO level became normal, but E-1 and WF went confidently down but still were above the upper limits of the norm